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MM11253

MM11253

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-108530-5mg
CASRN	345952-44-5
Available
Product Description	MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-programmed cell death
Formula	C28H30O2S2
References	[1].M I Dawson, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1; 91(1):8-21. \| [2].Q Le, et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9; 19(11):1457-65.
MolecularWeight	462.67
Research Area	Cancer
Solubility	DMSO : 125 mg/mL (270.17 mM; Need ultrasonic)
Target	RAR/RXR
Pathway	Metabolic Enzyme/Protease

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Amount: 5mg

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Delivery expected until 4/13/2023

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