Comparison

MM11253 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 5mg
Item no. HY-108530-5mg
CASRN 345952-44-5
Available
Product Description
MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists.
StorageTemperature
Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications
Cancer-programmed cell death
Formula
C28H30O2S2
References
[1].M I Dawson, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1; 91(1):8-21. | [2].Q Le, et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9; 19(11):1457-65.
MolecularWeight
462.67
Research Area
Cancer
Solubility
DMSO : 125 mg/mL (270.17 mM; Need ultrasonic)
Target
RAR/RXR
Pathway
Metabolic Enzyme/Protease

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 5mg
Available: In stock
available

Delivery expected until 4/13/2023 

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