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BL-1249

BL-1249

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-108596-50mg
CASRN	18200-13-0
Available
Product Description	BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM).
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Formula	C17H17N5
References	[1].Tertyshnikova S, et al. BL-1249 [(5, 6, 7, 8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J Pharmacol Exp Ther. 2005 Apr; 313(1):250-9. \| [2].Pope L, et al. Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels. ACS Chem Neurosci. 2018 Dec 19; 9(12):3153-3165. \| [3].Iwaki Y, et al. Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249. Bioorg Med Chem Lett. 2019 Jul 1; 29(13):1601-1604.
MolecularWeight	291.35
Research Area	Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (171.61 mM; ultrasonic and warming and heat to 60°C)
Target	Potassium Channel
Pathway	Membrane Transporter/Ion Channel

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Amount: 50mg

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Delivery expected until 4/20/2023

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