« Back
Home /
Icatibant (acetate)

Icatibant (acetate)

Item no.	HY-108896-10mg
Manufacturer	MedChem Express
CASRN	138614-30-9
Amount	10 mg
Quantity options	100 mg 10 mM x 1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.85
Citations	[1]Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73.\|[2]Y Arai, et al. Effect of Icatibant, a Bradykinin B2 Receptor Antagonist, on the Development of Experimental Ulcerative Colitis in Mice. Dig Dis Sci. 1999 Apr;44(4):845-51.\|[3]Marie-Thérèse Bawolak, et al The Bradykinin B2 Receptor Antagonist Icatibant (Hoe 140) Blocks Aminopeptidase N at Micromolar Concentrations: Off-Target Alterations of Signaling Mediated by the Bradykinin B1 and Angiotensin Receptors. Eur J Pharmacol. 2006 Dec 3;551(1-3):108-11. Adv Sci (Weinh). 2022 Oct 18;e2203088.\|Biochem Biophys Res Commun. 2024 Dec 31:746:151265.\|Biochem Biophys Res Commun. 2016 Apr 29;473(2):396-402. \|Biomed Pharmacother. 2024 Mar 20:174:116489.\|Br J Pharmacol. 2024 Jun 13.\|iScience. 2023 Jun 28.\|iScience. 2024 May 22.\|J Renin Angiotensin Aldosterone Syst. 14 Jun 2022.\|Nat Commun. 2023 May 2;14(1):2523.\|Sci Rep. 2020 Aug 25;10(1):14160.\|SSRN. 2023 Dec 27.
Smiles	CC(O)=O.O=C([C@@H]1N(CC2=CC=CC=C2C1)C([C@H](CO)NC([C@@H](NC(CNC([C@H]3N(C[C@H](O)C3)C([C@H]4N(CCC4)C([C@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC5=CC=CS5)=O)=O)N6[C@]7([H])[C@](CCCC7)([H])C[C@H]6C(N[C@H](C(O)=O)CCCNC(N)=N)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HOE 140 (acetate)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Bradykinin Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Molecular Weight	1364.57
Product Description	Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein
Isoform	Bradykinin B2 Receptor (B2R)
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-108896-10mg-safety-datasheet.pdf