Comparison

(Rac)-Modipafant European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 10mg
Item no. HY-108908-10mg
CASRN 122956-68-7
Available
Product Description
(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
StorageTemperature
Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications
COVID-19-immunoregulation
Formula
C34H29ClN6O3
References
[1].O'Connor BJ, et al. Inhibitory effect of UK, 74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. Am J Respir Crit Care Med. 1994; 150(1):35-40. | [2].Alabaster VA, et al. UK-74, 505, a novel and selective PAF antagonist, exhibits potent and long lasting activity in vivo. Agents Actions Suppl. 1991; 34:221-227. | [3].Parry MJ, Alabaster VA, et al. Pharmacological profile of UK-74, 505, a novel and selective PAF antagonist with potent and prolonged oral activity. J Lipid Mediat Cell Signal. 1994; 10(3):251-268. | [4].Guerrero AT, et al. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia [published correction appears in Naunyn Schmiedebergs Arch Pharmacol. 2013 Apr; 386(4):351. Zaperlon, Ana C [corrected to Zarpelon, Ana C]]. Naunyn Schmiedebergs Arch Pharmacol. 2013; 386(1):51-59. | [5].Souza DG, et al. Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection. Proc Natl Acad Sci U S A. 2009; 106(33):14138-14143.
MolecularWeight
605.09
Research Area
Infection; Inflammation/Immunology
Solubility
DMSO : 50 mg/mL (82.63 mM; Need ultrasonic)
Target
Others
Pathway
Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 10mg
Available: In stock
available

Delivery expected until 4/13/2023 

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