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Nacubactam

Nacubactam

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-109008-50mg
CASRN	1452458-86-4
Available
Product Description	Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.
StorageTemperature	-20°C, protect from light, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Applications	COVID-19-immunoregulation
Formula	C9H16N4O7S
References	[1].Monogue ML, et al. In Vivo Efficacy of Meropenem with a Novel Non-β-Lactam-β-Lactamase Inhibitor, Nacubactam, against Gram-Negative Organisms Exhibiting Various Resistance Mechanisms in a Murine Complicated Urinary Tract Infection Model. Antimicrob Agents Chemother. 2018 Aug 27; 62(9). \| [2].Livermore DM, et al. Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases. J Antimicrob Chemother. 2015 Nov; 70(11):3032-41.
MolecularWeight	324.31
Research Area	Infection
Solubility	DMSO : 250 mg/mL (770.87 mM; Need ultrasonic) \| H2O : 35.71 mg/mL (110.11 mM; Need ultrasonic)
Target	Bacterial
Pathway	Anti-infection

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Amount: 50mg

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Delivery expected until 4/20/2023

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