Comparison

Rolofylline European Partner

Item no. HY-10965-25mg
Manufacturer MedChem Express
CASRN 136199-02-5
Amount 25 mg
Quantity options 100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.68
Formula C20H28N4O2
Citations [1]Stroh M, et al. Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites. AAPS J. 2013 Apr;15(2):498-504.
[2]Dennissen FJ, et al. Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11597-11602. Epub 2016 Sep 26.
Smiles O=C(N1CCC)N(CCC)C2=C(N=C(C34CC(C5)CC3CC5C4)N2)C1=O
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias KW-3902
Shipping condition Cool pack
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Neuroscience-Neurodegeneration
Manufacturer - Targets
Adenosine Receptor
Shipping Temperature
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Molecular Weight
356.46
Product Description
Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment.
Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450)[1].
Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases[2].
Manufacturer - Research Area
Neurological Disease
Solubility
DMSO : 20 mg/mL (ultrasonic)
Manufacturer - Pathway
GPCR/G Protein
Clinical information
Phase 3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 mg
Available: In stock
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