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Rolofylline

Rolofylline

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	25mg
Item no.	HY-10965-25mg
CASRN	136199-02-5
Available
Product Description	Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Neuroscience-Neurodegeneration
Formula	C20H28N4O2
References	[1].Stroh M, et al. Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites. AAPS J. 2013 Apr; 15(2):498-504. \| [2].Dennissen FJ, et al. Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280. Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41):11597-11602. Epub 2016 Sep 26.
MolecularWeight	356.46
Research Area	Neurological Disease
Solubility	DMSO : 20 mg/mL (56.11 mM; Need ultrasonic)
Target	Adenosine Receptor
Pathway	GPCR/G Protein

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Amount: 25mg

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Delivery expected until 4/6/2023

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