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AZ 12216052

AZ 12216052

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	HY-110122-10mg
CASRN	1290628-31-7
Available
Product Description	AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Neuroscience-Neurodegeneration
Formula	C19H22BrNOS
References	[1].Reed BT, et al. Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds. Neuropharmacology. 2013 Apr; 67:88-94. \| [2].Jantas D, et al. Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State. Basic Clin Pharmacol Toxicol. 2018 Oct; 123(4):443-451. \| [3].Duvoisin RM, et al. Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav Brain Res. 2010 Oct 15; 212(2):168-73. \| [4].Duvoisin RM, et al. Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav Brain Res. 2011 Aug 1; 221(1):50-4.
MolecularWeight	392.35
Research Area	Neurological Disease
Target	mGluR
Isoform	mGlu8
Pathway	GPCR/G Protein; Neuronal Signaling

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Amount: 10mg

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Delivery expected until 4/13/2023

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