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Simvastatin-d6

Simvastatin-d6

Item no.	HY-110231-5mg
Manufacturer	MedChem Express
CASRN	1002347-71-8
Amount	5 mg
Quantity options	1 ea 1 mg 500 ug 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.6
Citations	[1]Slater E E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.;Kureishi, Y., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinas\|[2]Kureishi Y, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 2000 Sep;6(9):1004-10.\|[3]Slater EE, et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs. 1988;36 Suppl 3:72-82.
Smiles	CCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O3)C[C@H](CC3=O)O)=C[C@H](C)C1)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	MK 733-d6
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Apoptosis; Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR); Mitophagy
Shipping Temperature	Room temperature
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	424.60
Product Description	Simvastatin-d6 (MK 733-d6) is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Autophagy; Metabolic Enzyme/Protease
Clinical information	Phase 2

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