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Shield-1

Shield-1

Item no.	HY-112210-10mM
Manufacturer	MedChem Express
CASRN	914805-33-7
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.73
Dry ice	Yes
Citations	[1]Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11.\|[2]Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17(1):763-770.\|[3]Laura A Banaszynski, et al. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell. 2006 Sep 8;126(5):995-1004.
Smiles	O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Shld1
Shipping Condition	Dry ice
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	FKBP
Shipping Temperature	Dry Ice
Storage Conditions	-80°C, stored under nitrogen
Molecular Weight	748.90
Product Description	Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO: 67.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Clinical information	No Development Reported

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HY-112210-10mM-safety-datasheet.pdf