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diABZI STING agonist-1 (trihydrochloride)

diABZI STING agonist-1 (trihydrochloride)

Item no.	HY-112921B-50mg
Manufacturer	MedChem Express
CASRN	2138299-34-8
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.92
Formula	C42H54Cl3N13O7
Citations	ACS Infect Dis. 2022 Feb 8. Am J Cancer Res. 2023 May 30;13(5):2055-2065. Cancer Lett. 20 August 2022, 215885. Cancer Lett. 2024 Jun 21:217081. Cell Death Dis. 2022 Jul 28;13(7):653. Cell Immunol. 2021, 104384. Exp Hematol Oncol. 2024 Aug 5;13(1):77. Front Immunol. 2020 Jul 8;11:1430. Front Pharmacol. 2023 Apr 4;14:1160445. J Bone Miner Res. 2024 Jun 14:zjae093. J Ethnopharmacol. 2024 Aug 17:118661. J Invest Dermatol. 2021 Sep 24;S0022-202X(21)02227-2. Mol Cell. 2023 Apr 14;S1097-2765(23)00243-5. Nat Nanotechnol. 2021 Sep 30. OncoImmunology. 2022 Feb 1;11(1):2030021. PLoS One. 2021 Oct 27;16(10):e0258989. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2213777120. Protein Cell. 2021 Oct 22;1-21. Sci China Life Sci. 2024 Aug 22. Sci Rep. 2022 Oct 24;12(1):17827. Thorac Cancer. 2022 May; 13(9): 1361–1368. Biomed Pharmacother. 2024 Jan 2:171:116007. Cancer Lett. 2024 May 1:589:216836. Cell Death Differ. 2023 Nov 25. Chin Herb Med. 2024 Jul. Chin Med. 2024 Aug 15;19(1):107. Genes Dis. 2023 Sep 2. Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):13. J Exp Med. 2021 Feb 1;218(2):e20200887. University of California San Diego. 2023 [1]Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7.
Smiles	O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CC(OC)=C3N2C/C=C/CN4C5=C(OCCCN6CCOCC6)C=C(C(N)=O)C=C5N=C4NC(C7=CC(C)=NN7CC)=O.Cl.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	STING
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Product Description	diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 90 mg/mL (ultrasonic)\|H2O : 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation
Clinical information	No Development Reported

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HY-112921B-50mg-safety-datasheet.pdf