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Nusinersen

Nusinersen

Item no.	HY-112980-10mg
Manufacturer	MedChem Express
CASRN	1258984-36-9
Amount	10 mg
Quantity options	10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.62
Citations	[1]Richard S Finkel, et al. Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy. N Engl J Med. 2017 Nov 2;377(18):1723-1732.\|[2]Laura Torres-Benito, et al. NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice. Am J Hum Genet. 2019 Jul 3;105(1):221-230.\|[3]Berciano MT, et al. Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model. Sci Rep. 2020 Jul 1;10(1):10738.
Smiles	[Nusinersen]
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Oligonucleotides
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	DNA/RNA Synthesis
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	7127.3 (1mg=140nmol; 5mg=702nmol)
Product Description	Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy[1][2][3].
Manufacturer - Research Area	Neurological Disease
Solubility	10 mM in H2O
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	Launched

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HY-112980-10mg-safety-datasheet.pdf