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N1-Acetylspermidine (hydrochloride)

N1-Acetylspermidine (hydrochloride)

Item no.	HY-113056A-25mg
Manufacturer	MedChem Express
CASRN	34450-16-3
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.0
Citations	[1]Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84.\|[2]Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.\|[3]Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7.\|[4]Kato M, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2(10):pgad306.\|[5]Gossé F, et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 2006 Aug;29(2):423-8.
Smiles	CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	260.20
Product Description	N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research[1][2][3][4][5].
Manufacturer - Research Area	Cancer
Solubility	H2O: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-113056A-25mg-safety-datasheet.pdf