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Ursocholic acid

Ursocholic acid

Item no.	HY-113212-50mg
Manufacturer	MedChem Express
CASRN	2955-27-3
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.91
Formula	C24H40O5
Citations	[1]MacDonald IA, et al. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ Microbiol. 1982 Nov;44(5):1187-95. [2]Lee HI, et al. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1α, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Nov;52(11):981-5. [3]Ikegami, et al. Ursodeoxycholic acid: mechanism of action and novel clinical applications. Hepatology Research 38.2 (2008): 123-131. [4]Kim, et al. Ursodeoxycholic acid attenuates 5‑fluorouracil‑induced mucositis in a rat model. Oncology letters 16.2 (2018): 2585-2590. [5]Dubreuil, et al. Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells. Liver international 33.7 (2013): 1029-1038.
Smiles	C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2955-27-3
Similar products	2955-27-3
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Apoptosis; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	408.57
Product Description	Ursocholic acid, a bile acid present in mammalian bile, is converted to deoxycholic acid (UDC) by the mouse intestinal flora. Ursocholic acid acts as a gallstone dissolving agent in the liver through anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling, Ursocholic acid also has favorable effects on bones in patients with chronic cholestasis[1][2][3][4][5].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	No Development Reported

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HY-113212-50mg-safety-datasheet.pdf