SHP394

Item no.	HY-114397-5mg
Manufacturer	MedChem Express
CASRN	2055757-40-7
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.66
Citations	[1]Sarver P, et al. 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J Med Chem. 2019 Feb 28;62(4):1793-1802.
Smiles	NC1=C(C(N(C)C(N2CCC3(CO[C@@H](C)[C@H]3N)CC2)=N1)=O)SC4=C(C(F)(F)F)N=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2055757-40-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Phosphatase; SHP2
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	470.51
Product Description	SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 24 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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HY-114397-5mg-safety-datasheet.pdf