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8-Azaadenosine

8-Azaadenosine

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	25mg
Item no.	HY-115686-25mg
CASRN	10299-44-2
Available
Product Description	8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells.
StorageTemperature	-20°C, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Formula	C9H12N6O4
References	[1].Maria Anna Zipeto, et al. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 4; 19(2):177-191. \| [2].Julia Ramírez-Moya, et al. ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Oncogene. 2020 Apr; 39(18):3738-3753.
MolecularWeight	268.23
Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (932.04 mM; Need ultrasonic) \| H2O : 3.33 mg/mL (12.41 mM; ultrasonic and warming and heat to 60°C)
Target	Adenosine Deaminase
Pathway	Metabolic Enzyme/Protease

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Amount: 25mg

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Delivery expected until 4/6/2023

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