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PZ703b (TFA)

PZ703b (TFA)

Item no.	HY-115718A-10mg
Manufacturer	MedChem Express
Amount	10 mg
Quantity options	10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.62
Citations	[1]Yi Xu, et al. Mivebresib synergized with PZ703b, a novel Bcl-xl PROTAC degrader, induces apoptosis in bladder cancer cells via the mitochondrial pathway. Biochem Biophys Res Commun. 2022 Oct 1;623:120-126. \|[2]Pratik Pal, et al. Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition. J Med Chem. 2021 Oct 14;64(19):14230-14246.
Smiles	ClC1=CC=C(C=C1)C2=C(C[C@](CNC(CCCCCCCCC(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@@H](C)C4=CC=C(C=C4)C5=C(N=CS5)C)=O)O)=O)C(C)(C)C)=O)=O)(CC2)C)CN6CCN(CC6)C7=CC=C(C=C7)C(NS(C8=CC(S(=O)(C(F)(F)F)=O)=C(C=C8)N[C@H](CCN9CCOCC9)CSC%10=CC=CC=C%10)(=O)=O)=O.OC(C(F)(F)F)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Bcl-2 Family; PROTACs
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light)
Molecular Weight	1714.46
Product Description	PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research[1][2].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; PROTAC
Isoform	Bcl-xL
Clinical information	No Development Reported

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HY-115718A-10mg-safety-datasheet.pdf