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Ro 41-5253

Ro 41-5253

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	25mg
Item no.	HY-116248-25mg
CASRN	144092-31-9
Available
Product Description	Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity.
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Cancer-programmed cell death
Formula	C28H36O5S
References	[1].S Toma, et al. RARalpha antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines. Int J Cancer. 1998 Sep 25; 78(1):86-94 \| [2].Salvatore Toma, et al. Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-alpha. Cancer Lett. 2005 Feb 28; 219(1):27-31. doi: 10.1016/j.canlet.2004.06.018. \| [3].C Apfel, et al. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A. 1992 Aug 1; 89(15):7129-33.
MolecularWeight	484.65
Research Area	Cancer
Target	RAR/RXR; Apoptosis
Pathway	Metabolic Enzyme/Protease; Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 25mg

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Delivery expected until 4/13/2023

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