Comparison

PF-06685249 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 25mg
Item no. HY-117623-25mg
CASRN 1467059-70-6
Available
Product Description
PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research.
StorageTemperature
Please store the product under the recommended conditions in the Certificate of Analysis.
Applications
Metabolism-sugar/lipid metabolism
Formula
C17H16ClN3O3
References
[1].David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22; 61(6):2372-2383.
MolecularWeight
345.78
Research Area
Metabolic Disease
Solubility
DMSO : 100 mg/mL (289.20 mM; Need ultrasonic)
Target
AMPK
Isoform
AMPK α1β1γ1
Pathway
Epigenetics; PI3K/Akt/mTOR

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 25mg
Available: In stock
available

Delivery expected until 4/13/2023 

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