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PF-06685249

PF-06685249

Item no.	HY-117623-25mg
Manufacturer	MedChem Express
CASRN	1467059-70-6
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.32
Formula	C17H16ClN3O3
Citations	[1]David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383.
Smiles	O=C(C1=CNC2=C1C=C(C3=CC=C(N(C)C)N=C3OC)C(Cl)=C2)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PF-249
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	AMPK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	345.78
Product Description	PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research[1].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics; PI3K/Akt/mTOR
Isoform	AMPK α1β1γ1
Clinical information	No Development Reported

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HY-117623-25mg-safety-datasheet.pdf