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PF-06685249

PF-06685249

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	25mg
Item no.	HY-117623-25mg
CASRN	1467059-70-6
Available
Product Description	PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research.
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Metabolism-sugar/lipid metabolism
Formula	C17H16ClN3O3
References	[1].David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22; 61(6):2372-2383.
MolecularWeight	345.78
Research Area	Metabolic Disease
Solubility	DMSO : 100 mg/mL (289.20 mM; Need ultrasonic)
Target	AMPK
Isoform	AMPK α1β1γ1
Pathway	Epigenetics; PI3K/Akt/mTOR

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 25mg

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Delivery expected until 4/13/2023

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