OB-24

Item no.	HY-118487-10mg
Manufacturer	MedChem Express
CASRN	939825-12-4
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.03
Citations	[1]Alaoui-Jamali MA, et al. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009;69(20):8017-8024.\|[2]Moulay. Alaoui-Jamali, et al., OB-24, a novel selective and potent HO-1 inhibitor, induces a wide spectrum anti-tumor activity in vitro and in vivo and synergizes with chemotherapy drugs. Mol Cancer Ther 1 November 2007; 6 (11_Supplement): C82.\|[3]Roman, G., et al., (2007). Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorganic & medicinal chemistry, 15(9), 3225–3234.
Smiles	BrC1=CC=C(CCC2(CN3C=CN=C3)OCCO2)C=C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Heme Oxygenase (HO); Reactive Oxygen Species (ROS)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	373.67
Product Description	OB-24 is a selective small-molecule HO-1 inhibitor (IC50 = 1.9 μM for HO-1 and IC50 for HO-2 >100 μM). OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Isoform	HO-1; HO-2
Clinical information	No Development Reported

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HY-118487-10mg-safety-datasheet.pdf