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Vacuolin-1

Vacuolin-1

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-118630-50mg
CASRN	351986-85-1
Available
Product Description	Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation.
StorageTemperature	-20°C, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Applications	COVID-19-immunoregulation
Formula	C26H24IN7O
References	[1].Jan Cerny, et al.The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep; 5(9):883-8. \| [2].Osamu Sano, et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016 Jun; 590(11):1576-85. \| [3].Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy
MolecularWeight	577.42
Research Area	Cancer
Solubility	DMSO : 10 mg/mL (17.32 mM; Need ultrasonic)
Target	PIKfyve; Autophagy
Pathway	PI3K/Akt/mTOR; Autophagy

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Amount: 50mg

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Delivery expected until 4/13/2023

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