Comparison

Vacuolin-1 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-118630-50mg
CASRN 351986-85-1
Available
Product Description
Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation.
StorageTemperature
-20°C, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Applications
COVID-19-immunoregulation
Formula
C26H24IN7O
References
[1].Jan Cerny, et al.The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep; 5(9):883-8. | [2].Osamu Sano, et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016 Jun; 590(11):1576-85. | [3].Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy
MolecularWeight
577.42
Research Area
Cancer
Solubility
DMSO : 10 mg/mL (17.32 mM; Need ultrasonic)
Target
PIKfyve; Autophagy
Pathway
PI3K/Akt/mTOR; Autophagy

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
available

Delivery expected until 4/13/2023 

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