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Advantame (free acid)

Advantame (free acid)

Item no.	HY-122351
Manufacturer	MedChem Express
CASRN	245650-17-3
Amount	1 ea
Quantity options	1 ea 10 mg 5 mg
Category	Food Safety Inhibitors & Compound Libraries Small Molecules Food Additives Sweeteners
Type	Inhibitors
Specific against	other
Citations	[1]A Otabe, et al. Advantame--an overview of the toxicity data. Food Chem Toxicol . 2011 Nov:49 Suppl 1:S2-7.\|[2]DENISA IOANA VOICULESCU, et al., (2021) COMPUTATIONAL ASSESSMENT OF THE PHARMACOKINETICS AND TOXICITY OF THE INTENSIVE SWEETENERS: Farmacia, 69, 6. \|[3]EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), (2013), Scientific Opinion on the safety of advantame for the proposed uses as a food additive, 11(7).\|[4]Skapinker, E., et al., (2024). Artificial and Natural Sweeteners Biased T1R2/T1R3 Taste Receptors Transactivate Glycosylated Receptors on Cancer Cells to Induce Epithelial-Mesenchymal Transition of Metastatic Phenotype. Nutrients, 16(12), 1840.
Smiles	OC1=C(OC)C=CC(CCCN[C@@H](CC(O)=O)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	Drug Derivative; Taste Receptor
Shipping Temperature	Room temperature
Molecular Weight	458.50
Product Description	Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K+ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits[1][2][3].
Manufacturer - Research Area	Others
Solubility	10 mM in DMSO
Manufacturer - Pathway	GPCR/G Protein; Others
Clinical information	No Development Reported
UNSPSC Code	12352005

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