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Nargenicin A1

Nargenicin A1

Item no.	HY-123121-5mg
Manufacturer	MedChem Express
CASRN	70695-02-2
Amount	5 mg
Quantity options	1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C28H37NO8
Citations	[1]Da Hye Kwon, et al. Nargenicin A1 attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB signaling pathway. EXCLI J. 2021 May 28;20:968-982. [2]Dhakal D, et al. Characterization of Tailoring Steps of Nargenicin A1 Biosynthesis Reveals a Novel Analogue with Anticancer Activities. ACS Chem Biol. 2020 Jun 19;15(6):1370-1380.
Smiles	C/C([C@]12O[C@@H]([C@@H]([C@@H]([C@H]([C@]32[H])O)C)OC(C4=CC=CN4)=O)[C@]3([H])C=C[C@]1([H])C[C@@H]5OC)=C\[C@H]([C@]([H])(OC5=O)[C@H](O)C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Apoptosis; Bacterial; NF-κB
Shipping Temperature	Room Temperature
Molecular Weight	515.60
Product Description	Nargenicin A1 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia[1].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Anti-infection; Apoptosis; NF-κB
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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