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c-di-AMP (disodium)

c-di-AMP (disodium)

Item no.	HY-12326A-25mg
Manufacturer	MedChem Express
CASRN	2734909-87-4
Amount	25 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 500 ug 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.71
Formula	C20H22N10Na2O12P2
Dry ice	Yes
Citations	Cell Death Dis. 2022 Jul 28;13(7):653. Gut Microbes. 2022 Jan-Dec;14(1):2119055. [1]Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8). [2]Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519. [3]Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31. [4]Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824.
Smiles	O[C@H]([C@@](OP(OC[C@](O[C@@H](N1C2=NC=NC(N)=C2N=C1)[C@@H]3O)([H])[C@@]3([H])O4)(O[Na])=O)([H])[C@](COP4(O[Na])=O)([H])O5)[C@@H]5N6C7=NC=NC(N)=C7N=C6
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Cyclic diadenylate (disodium), Cyclic-di-AMP (disodium)
Shipping condition	Dry ice
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Bacterial; Endogenous Metabolite; STING
Shipping Temperature	Dry Ice
Storage Conditions	-80°C, protect from light, stored under nitrogen
Molecular Weight	702.38
Product Description	c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO : 270 mg/mL (ultrasonic)\|H2O : ≥ 50 mg/mL
Manufacturer - Pathway	Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-12326A-25mg-safety-datasheet.pdf