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SEC inhibitor KL-2

SEC inhibitor KL-2

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10mM/1mL
Item no.	HY-123972-10mM
Targets	Others
CASRN	900308-51-2
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	333.74
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 83.33 mg/mL (ultrasonic)
Manufacturers Target	Others
Pathway	Others
Manufacturers Product type	Reference compound

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HY-123972-10mM-safety-datasheet.pdf