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ζ-Stat (trisodium)

ζ-Stat (trisodium)

Item no.	HY-123979A-50mg
Manufacturer	MedChem Express
CASRN	31894-34-5
Amount	50 mg
Quantity options	100 mg 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	97.0
Citations	[1]Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.\|[2]Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.
Smiles	O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NSC37044 (trisodium)
Similar products	31894-34-5
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; PKC
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	450.31
Product Description	ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].
Manufacturer - Research Area	Cancer
Solubility	H2O: 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis; Epigenetics; TGF-beta/Smad
Isoform	PKCζ
Clinical information	No Development Reported

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