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T-3364366

T-3364366

Item no.	HY-124346-5mg
Manufacturer	MedChem Express
CASRN	1356354-09-0
Amount	5 mg
Quantity options	10 mg 1 ea 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.80
Citations	[1]Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72.
Smiles	CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(OCC(F)(F)F)C=C3)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Stearoyl-CoA Desaturase (SCD)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	443.46
Product Description	T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD, 50 >10000 nM) in the enzymatic activity assay[1].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-124346-5mg-safety-datasheet.pdf