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δ-Secretase inhibitor 11

δ-Secretase inhibitor 11

Item no.	HY-124832-50mg
Manufacturer	MedChem Express
CASRN	842964-18-5
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.06
Formula	C10H12N4O2
Citations	[1]Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27;8:14740.
Smiles	NC1=CC=C(N2CCOCC2)C3=NON=C31
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Amyloid-β; Caspase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Product Description	δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research[1].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Neuronal Signaling
Isoform	Caspase 3; Caspase 8
Clinical information	No Development Reported

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