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δ-Secretase inhibitor 11

δ-Secretase inhibitor 11

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-124832-50mg
CASRN	842964-18-5
Available
Product Description	δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research.
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Neuroscience-Neurodegeneration
Formula	C10H12N4O2
References	[1].Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27; 8:14740.
MolecularWeight	220.23
Research Area	Neurological Disease
Target	Caspase; Amyloid-β
Isoform	Caspase-3; Caspase-8
Pathway	Apoptosis; Neuronal Signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 50mg

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Delivery expected until 4/13/2023

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