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GSK-843

GSK-843

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-125402-50mg
CASRN	1601496-05-2
Available
Product Description	GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	COVID-19-immunoregulation
Formula	C19H15N5S2
References	[1].Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25; 288(43):31268-79. \| [2].Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20; 56(4):481-95.
MolecularWeight	377.49
Research Area	Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (132.45 mM; Need ultrasonic)
Target	RIP kinase; Apoptosis
Pathway	Apoptosis

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Amount: 50mg

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Delivery expected until 4/13/2023

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