CP-10

Item no.	HY-125835-5mg
Manufacturer	MedChem Express
CASRN	2366268-80-4
Amount	5 mg
Quantity options	10 mMx1 mL 10 mg 1 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.41
Citations	[1]Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
Smiles	CC(C(C1=O)=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)N=N5)CC4)C=N3)N=C2N1C9CCCC9)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2366268-80-4
Similar products	2366268-80-4
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CDK; PROTACs
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	871.94
Product Description	CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 200 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; PROTAC
Isoform	CDK6; Cereblon
Clinical information	No Development Reported

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HY-125835-5mg-safety-datasheet.pdf