Comparison

Polyquaternium-1 European Partner

Item no. HY-127032-10mg
Manufacturer MedChem Express
CASRN 75345-27-6
Amount 10 mg
Quantity options 100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category
Type Inhibitor
Specific against other
Purity 99.0
Citations [1]Paimela T, et al. The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells. Mol Vis. 2012;18:1189-96. Epub 2012 May 6.|[2]Rolando M, et, al. Ophthalmic preservatives: focus on polyquaternium-1. Expert Opin Drug Deliv. 2011 Nov;8(11):1425-38.|[3]Mohamed YH, et al. Acute Corneal Toxicity of Combined Antiglaucoma Topical Eyedrops. Curr Eye Res. 2016 Oct;41(10):1326-1330.
Smiles OCC[N+](CCO)(C/C=C/C[N+](C)(C/C=C/C[N+](CCO)(CCO)CCO)C)CCO.[3 Cl-].[n]
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias Polidronium (chloride)
Shipping Condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
COVID-19-immunoregulation
Manufacturer - Targets
Biochemical Assay Reagents
Shipping Temperature
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Description
Polyquaternium-1 (Polidronium chloride; PQ-1) is an antimicrobial preservative and an activator of NF-κB. Polyquaternium-1 targets bacterial cell membranes, commonly used in ophthalmic surgery. Polyquaternium-1 adsorbs to the surface of microbial membranes through its polycationic properties, destroying membrane integrity and inducing potassium ion leakage, leading to bacterial death. Polyquaternium-1 exerts antimicrobial effects at a concentration of 0.001% and has low toxicity to mammalian cells. Polyquaternium-1 can be used to prepare products such as glaucoma eye drops (Travoprost preparations containing PQ-1), artificial tears, and contact lens solutions to reduce the ocular surface toxicity of traditional preservatives such as benzalkonium chloride (HY-B2232)[1][2][3].
Manufacturer - Research Area
Infection
Solubility
H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway
Others
Clinical information
Phase 4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
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