Comparison

ddATP trisodium European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 25mg
Item no. HY-128036B-25mg
CASRN 72029-21-1
Available
Product Description
ddATP (2', 3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2', 3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection.
StorageTemperature
-20°C, protect from light, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Applications
COVID-19-anti-virus
Formula
C10H13N5Na3O11P3
References
[1].van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2', 3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28; 20(9):2628-32. | [2].Xu Lan, et al. Simultaneous determination of 2 , 3 -dideoxyinosine and the active metabolite, 2 , 3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1; 1002:337-42. | [3].Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24; 218(2):iyab054. | [4].C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec; 52(6):928-62. | [5].Hao Z, et al. Factors determining the activity of 2', 3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct; 34(4):431-5.
MolecularWeight
541.13
Research Area
Infection
Solubility
H2O : 125 mg/mL (231.00 mM; Need ultrasonic)
Target
DNA/RNA Synthesis; HIV
Pathway
Cell Cycle/DNA Damage; Anti-infection

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 25mg
Available: In stock
available

Delivery expected until 4/6/2023 

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