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ddATP (trisodium)

ddATP (trisodium)

Item no.	HY-128036B-25mg
Manufacturer	MedChem Express
CASRN	72029-21-1
Amount	25 mg
Quantity options	100 mg 10 mg 25 mg 27 mg (100 mM * 0.5 mL in Water) 50 mg 54 mg (100 mM * 1 mL in Water) 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28;20(9):2628-32. [2]Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42. [3]Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24;218(2):iyab054. [4]C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52(6):928-62. [5]Hao Z, et al. Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct;34(4):431-5.
Smiles	NC1=NC=NC2=C1N=CN2[C@H](O3)CC[C@H]3COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2',3'-Dideoxyadenosine 5'-triphosphate (trisodium)
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	DNA/RNA Synthesis; HIV
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Product Description	ddATP (2', 3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2', 3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection[1][2][4].
Manufacturer - Research Area	Infection
Solubility	10 mM in H2O
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-128036B-25mg-safety-datasheet.pdf