ddATP trisodium

ddATP (2', 3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2', 3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection.

COVID-19-anti-virus

[1].van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2', 3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28; 20(9):2628-32. | [2].Xu Lan, et al. Simultaneous determination of 2 , 3 -dideoxyinosine and the active metabolite, 2 , 3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1; 1002:337-42. | [3].Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24; 218(2):iyab054. | [4].C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec; 52(6):928-62. | [5].Hao Z, et al. Factors determining the activity of 2', 3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct; 34(4):431-5.

Infection

DNA/RNA Synthesis; HIV