Comparison

TAS4464 European Partner

Item no. HY-128586-25mg
Manufacturer MedChem Express
CASRN 1848959-10-3
Amount 25 mg
Quantity options 10 mM/1 mL 10 mg 25 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.52
Formula C21H23FN6O6S
Citations [1]Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.
Smiles NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[C@@H]4O[C@H](CNS(=O)(N)=O)[C@@H](O)[C@H]4O
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Shipping condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Cancer-programmed cell death
Manufacturer - Targets
NEDD8-activating Enzyme
Shipping Temperature
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight
506.51
Product Description
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1].
Manufacturer - Research Area
Cancer
Solubility
DMSO : 40 mg/mL (ultrasonic)
Manufacturer - Pathway
Metabolic Enzyme/Protease
Clinical information
Phase 1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 mg
Available: In stock
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