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Abemaciclib metabolite M2-d6

Abemaciclib metabolite M2-d6

Item no.	HY-128669S-1ea
Manufacturer	MedChem Express
Amount	1 ea
Quantity options	1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.25
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).
Smiles	CC1=NC2=C(C=C(C3=C(C=NC(NC4=CC=C(C=N4)CN5CCNCC5)=N3)F)C=C2N1C(C([2H])([2H])[2H])C([2H])([2H])[2H])F
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	LSN2839567-d6
Shipping Condition	Cool pack
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	CDK
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	484.58
Product Description	Abemaciclib metabolite M2-d6 is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 2.12 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	No Development Reported

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