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GSK3368715

GSK3368715

Item no.	HY-128717-1ea
Manufacturer	MedChem Express
CASRN	1629013-22-4
Amount	1 ea
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.24
Citations	[1]Fedoriw A, et al. Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell. 2019 Jul 8;36(1):100-114.e25. Bone Rep. 2023 Jul 25, 101704.\|FASEB J. 2025 Jan 15;39(1):e70293.\|Mol Carcinog. 2023 May 5.\|Research Square Print. 26 Oct, 2022\|Research Square Print. September 20th, 2022.\|University of Munich. Fakultät für Medizin. 2022 Oct.\|Cell Death Dis. 2021 Nov 13;12(11):1080.\|Cell Rep. 2023 Mar 29;42(4):112316.\|Cell Rep. 2024 Aug 22;43(9):114662.\|Front Pharmacol. 2020 Sep 8;11:569661.\|Mol Carcinog. 2023 May 5.\|Nat Chem Biol. 2024 Oct 16.\|Nat Commun. 2023 Feb 23;14(1):1011.\|Patent. US20240261260A1.\|Research Square Preprint. 2022 Jul.\|Sci Adv. 2023 Sep 8;9(36):eadi2232.\|Transl Oncol. 2025 Jan 3:52:102264.
Smiles	CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	EPZ019997
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Histone Methyltransferase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	366.54
Product Description	GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Epigenetics
Isoform	PRMT1; PRMT3; PRMT4; PRMT6; PRMT8
Clinical information	Phase 1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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