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Eprodisate

Eprodisate

Item no.	HY-128849-500mg
Manufacturer	MedChem Express
CASRN	21668-77-9
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Dember LM, et al. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2349-60.\|[2]Manenti L, et al. Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother. 2008 Aug;9(12):2175-80.\|[3]Quaranta DV, et al. Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation. J Pharmacol Exp Ther. 2023 Jan;384(1):205-223.
Smiles	O=S(CCCS(=O)(O)=O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	21668-77-9
Similar products	21668-77-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Amyloid-β
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	204.22
Product Description	Eprodisate is an amyloid inhibitor that interferes with the interaction between amyloidogenic proteins and glycosaminoglycans, thereby inhibiting the aggregation of amyloid fibrils and the deposition of fibrils in tissues. Eprodisate slows the progression of renal disease associated with AA amyloidosis and may be useful for other types of amyloidosis[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: ≥ 125 mg/mL
Manufacturer - Pathway	Neuronal Signaling
Clinical information	Phase 3

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HY-128849-500mg-safety-datasheet.pdf