(S,R)-GSK321

Reference compound

Isocitrate Dehydrogenase (IDH)

-20°C, 3 years; 4°C, 2 years (Powder)

(S, R)-GSK321 is the (S, R)-enantiomer of GSK321 (HY-18948). GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers[1].

DMSO: 100 mg/mL (ultrasonic)

IDH1