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Cefminox (sodium)

Cefminox (sodium)

Item no.	HY-128932-25mg
Manufacturer	MedChem Express
CASRN	75498-96-3
Amount	25 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Citations	[1]Inouye S, et al. In vitro and in vivo antibacterial activities of MT-141, a new semisynthetic cephamycin, compared with those of five cephalosporins. Antimicrob Agents Chemother. 1984 Nov;26(5):722-9.\|[2]Xia J, et al. Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats. Front Pharmacol. 2018 Feb 23;9:134.
Smiles	O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(CSC[C@@H](N)C(O)=O)=O)C1=O)O[Na]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MT-141
Similar products	75498-96-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Akt; Antibiotic; Bacterial; mTOR; PPAR; Prostaglandin Receptor; PTEN
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	541.56
Product Description	Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model[1][2].
Manufacturer - Research Area	Infection; Cardiovascular Disease; Endocrinology
Solubility	H2O: 83.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Isoform	IP; PPARγ
Clinical information	Launched

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HY-128932-25mg-safety-datasheet.pdf