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MCL-1/BCL-2-IN-1

MCL-1/BCL-2-IN-1

Item no.	HY-129681-10mM
Manufacturer	MedChem Express
CASRN	2493256-46-3
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Cell Biology Cell Status Apoptosis Autophagy Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.86
Citations	[1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
Smiles	O=C(N(CCNC(C1=CC=C(C(C)(C)C)C=C1)=O)C2=O)C3=CC=C(SC4=CC=C(Br)C=C4)C5=C3C2=CC=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Bcl-2 Family
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	587.53
Product Description	MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 10 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis
Isoform	Bcl-2; Mcl-1
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-129681-10mM-safety-datasheet.pdf