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Azido-PEG8-NHS ester

Azido-PEG8-NHS ester

Item no.	HY-130184-25mg
Manufacturer	MedChem Express
CASRN	1204834-00-3
Amount	25 mg
Quantity options	100 mg 25 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C23H40N4O12
Citations	[1]Mahendra Persaud Deonarain, et al. Biological materials and uses thereof. WO2016046574A1. [2]Rong Yuan, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Analytical Chemistry (Washington, DC, United States) (2019), 91(8), 4948-4952.
Smiles	O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Cool pack
Available
Manufacturer - Type	ADC Related
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	ADC Linker; PROTAC Linkers
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	564.58
Product Description	Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related; PROTAC
Isoform	Alkyl/ether Linkers; Cleavable Linker; PEG Linkers
Clinical information	No Development Reported

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HY-130184-25mg-safety-datasheet.pdf