Bromo-PEG2-C2-azide

ADC Related

ADC Linker; PROTAC Linkers

-20°C (Powder, stored under nitrogen)

Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

DMSO: 100 mg/mL (ultrasonic)

Non-cleavable Linker; PEG Linkers