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PROTAC EED degrader-2

PROTAC EED degrader-2

Item no.	HY-130615-25mg
Manufacturer	MedChem Express
CASRN	2639882-69-0
Amount	25 mg
Quantity options	10 mg 1 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.90
Citations	[1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
Smiles	FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C4=NN=CN34)C5=C(N=C(C=C5)CCC(NCCCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=O)C
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Histone Methyltransferase; PROTACs
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	960.13
Product Description	PROTAC EED degrader-2 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9.27. PROTAC EED degrader-2 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.11) targeting the EED subunit[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 80 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics; PROTAC
Isoform	von Hippel-Lindau (VHL)
Clinical information	No Development Reported

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HY-130615-25mg-safety-datasheet.pdf