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BMS-1166-N-piperidine-CO-N-piperazine

BMS-1166-N-piperidine-CO-N-piperazine

Item no.	HY-131386-1ea
Manufacturer	MedChem Express
CASRN	2447066-14-8
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Formula	C41H43ClN4O5
Citations	[1]Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.
Smiles	O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)N7CCNCC7
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Target Protein Ligand-Linker Conjugates
Shipping Temperature	Room Temperature
Molecular Weight	707.26
Product Description	BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	PROTAC
Clinical information	No Development Reported

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