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6-Azuridine

6-Azuridine

Item no.	HY-131611-10mM
Manufacturer	MedChem Express
CASRN	54-25-1
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 1 g 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Citations	[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.\|[2]Yallappa G N, et al. Design and synthesis of pyrazole derivatives for in vitro screening to protect angiotensin-converting enzyme 2 human cells against COVID-19. Current Medicine Research and Practice, 2021, 11(5): 206-210.\|[3]Janeway CM, et al. Effects of 6-azauridine on nucleotides, orotic acid, and orotidine in L5178Y mouse lymphoma cells in vitro. Cancer Res. 1977 Dec;37(12):4382-8. \|[4]Cha YE, et al. 6-Azauridine Induces Autophagy-Mediated Cell Death via a p53- and AMPK-Dependent Pathway. Int J Mol Sci. 2021 Mar 14;22(6):2947.\|[5]Steffenhagen KA, et al. Evaluation of 6-azauridine and 5-iododeoxyuridine in the treatment of experimental viral infections. J Infect Dis. 1976 Jun;133(6):603-12.\|[6]Conn HO, et al. Effect of 6-azauridine on plasma cell tumors of mice: correlation of antitumor effect with inhibition of orotic acid metabolism. Cancer Res. 1967 Apr;27(4):618-25.
Smiles	O=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)N=CC1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	6-Azauridine
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	AMPK; Apoptosis; Autophagy; MDM-2/p53; Nucleoside Antimetabolite/Analog; SARS-CoV
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	245.19
Product Description	6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux, induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities[1][2][3][4][5][6].
Manufacturer - Research Area	Cancer; Infection; Others
Solubility	DMSO: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Clinical information	No Development Reported

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HY-131611-10mM-safety-datasheet.pdf