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MLT-231

MLT-231

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-131902-100mg
Available
Product Description	MLT-231 is a potent, highly selective allosteric MALT1 Inhibitor with an IC50 of 9 nM. MLT-231 specifically prevents endogenous BCL10 cleavage with IC50 of 160 nM. MLT-231 shows antitumor activity in an ABC-DLBCL type xenograft model in mouse.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-programmed cell death
Formula	C19H19ClF3N7O2
References	[1].Pissot Soldermann C, et al. Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing [published online ahead of print, 2020 Nov 30]. J Med Chem. 2020; 10.1021/acs.jmedchem.0c01245.
MolecularWeight	469.85
Research Area	Cancer
Solubility	DMSO : 110 mg/mL (234.12 mM; Need ultrasonic)
Target	MALT1
Pathway	Metabolic Enzyme/Protease; NF-κB

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Amount: 100mg

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Delivery expected until 4/6/2023

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