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Fitusiran

Fitusiran

Item no.	HY-132587-1ea
Manufacturer	MedChem Express
CASRN	1499251-18-1
Amount	1 ea
Quantity options	10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	94.68
Citations	[1]Pasi KJ, et al. Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort. J Thromb Haemost. 2021;19(6):1436-1446.
Smiles	[Fitusiran]
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ALN-AT3SC,SAR439774
Shipping Condition	Room temperature
Available
Manufacturer - Type	Oligonucleotides
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Factor Xa; Small Interfering RNA (siRNA)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	16248.2 (AS: 7675 + SS: 8573.2)
Product Description	Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia[1].
Manufacturer - Research Area	Others
Solubility	H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics; Metabolic Enzyme/Protease
Clinical information	Launched

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