Comparison

Dacomitinib-d10 European Partner

Item no. HY-13272S3-1mg
Manufacturer MedChem Express
Amount 1 mg
Quantity options 1 mg 5 mg
Category
Type Inhibitors
Specific against other
Citations [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Engelman JA, et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to ZD1839. Cancer Res. 2007 Dec 15;67(24):11924-32.|[3]Kalous O, et al. Dacomitinib (PF-00299804), an irreversible Pan-HER inhibitor, inhibits proliferation of HER2-amplified breast cancer cell lines resistant to Anti-Human HER2 and GW572016. Mol Cancer Ther. 2012 Sep;11(9):1978-87.
Smiles COC(C(NC(/C=C/CN1C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H])=O)=C2)=CC3=C2C(NC4=CC(Cl)=C(C=C4)F)=NC=N3
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias PF-00299804-d10,PF-299804-d10
Shipping Condition Room temperature
Available
Manufacturer - Type
Isotope-Labeled Compounds
Manufacturer - Applications
Cancer-Kinase/protease
Manufacturer - Targets
Apoptosis; EGFR; Isotope-Labeled Compounds
Shipping Temperature
Room temperature
Molecular Weight
480.00
Product Description
Dacomitinib-d10 is deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively[1].
Manufacturer - Research Area
Cancer
Solubility
10 mM in DMSO
Manufacturer - Pathway
Apoptosis; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 mg
Available: In stock
available

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