SJF620

Item no.	HY-133137-5mg
Manufacturer	MedChem Express
CASRN	2376187-16-3
Amount	5 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.98
Citations	[1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
Smiles	O=C(C(N(CC1=C2C=CC(OCCOCCOCCN3CCC(N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C7=C(N)N=CN=C74)CC3)=C1)C2=O)CC8)NC8=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2376187-16-3
Similar products	2376187-16-3
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Btk; PROTACs
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	760.84
Product Description	SJF620 is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	PROTAC; Protein Tyrosine Kinase/RTK
Isoform	Cereblon
Clinical information	No Development Reported

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HY-133137-5mg-safety-datasheet.pdf