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DBCO-PEG4-VA-PBD

DBCO-PEG4-VA-PBD

Item no.	HY-133433-1ea
Manufacturer	MedChem Express
CASRN	2241644-09-5
Amount	1 ea
Quantity options	10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.68
Dry ice	Yes
Citations	[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Smiles	[H][C@]12N(C(C3=CC(OC)=C(OCCCOC4=C(C=C5C(N=C[C@@]6([H])N(C=C(C7=CC=C(OC)C=C7)C6)C5=O)=C4)OC)C=C3N=C2)=O)C=C(C8=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCC(N9C%10=CC=CC=C%10C#CC%11=CC=CC=C%11C9)=O)=O)=O)=O)=O)C=C8)C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Dry ice
Available
Manufacturer - Type	ADC Related
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Drug-Linker Conjugates for ADC
Shipping Temperature	Dry Ice
Storage Conditions	-80°C, stored under nitrogen
Molecular Weight	1430.60
Product Description	DBCO-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA[1]. DBCO-PEG4-VA-PBD is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 120 mg/mL (ultrasonic)
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related
Isoform	Traditional Cytotoxic Agents
Clinical information	No Development Reported

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HY-133433-1ea-safety-datasheet.pdf