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Aminohexylgeldanamycin

Aminohexylgeldanamycin

Item no.	HY-133571-5mg
Manufacturer	MedChem Express
CASRN	485395-71-9
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.82
Citations	[1]Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.\|[2]Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.
Smiles	O=C(C(NCCCCCCN)=C1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(C)\C2=O)C=C(N2)C1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AHGDM
Shipping Condition	Cool pack
Available
Manufacturer - Type	ADC Related
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	ADC Cytotoxin; HSP
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light)
Molecular Weight	644.80
Product Description	Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 110 mg/mL (ultrasonic)
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Isoform	HSP90
Clinical information	No Development Reported

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HY-133571-5mg-safety-datasheet.pdf