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AP-1/NF-κB activation inhibitor 1

AP-1/NF-κB activation inhibitor 1

Item no.	HY-133987-100mg
Manufacturer	MedChem Express
CASRN	188936-12-1
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Aging & Neurological Disorders By Cell Type Hematology Myeloma Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.08
Citations	[1]Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;10(15):1645-1648.
Smiles	O=C(C1=CN=C(C(F)(F)F)N=C1NN2C(C(C)=CC2=O)=O)OCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	188936-12-1
Similar products	188936-12-1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	NF-κB
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	344.25
Product Description	AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	NF-κB
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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